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Several MAP kinases are involved in
2024-02-22
Several MAP kinases are involved in the signal transduction pathways that lead to the upregulations of inflammatory mediators. Moreover, transcriptional activations of STATs are regulated by MAP kinases, as evidenced by reports that p38 MAPK is necessary for the S727 phosphorylation of STATs (Kovari
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Furthermore different s http www apexbt
2024-02-22
Furthermore, different studies have described the APP as useful biomarkers in monitoring the post-ovariohysterectomy period in bitches with pyometra [12,14,52,53], similar to what was observed in queens in the present study. In our study, significant decreases in concentrations of a major (SAA) and
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Natural compounds present in medicinal
2024-02-21
Natural compounds, present in medicinal and/or nutritional plants as well as in macrofungi sources, have stimulated a great interest from the pharmaceutical industry. Different natural compounds such as phenolic compounds, alkaloids, terpenoids among others, have shown strong antiangiogenic effects
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Dual acting RAAS blockade and neprilysin inhibition
2024-02-21
Dual-acting RAAS blockade and neprilysin inhibition has been evaluated in several clinical HF trials. In PARADIGM-HF [6,7], LCZ696 was superior to enalapril in reducing mortality and HF hospitalizations in symptomatic patients with HF with reduced EF. Augmented benefits on maladaptive cardiac remode
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br Duality of interest br Contribution statement
2024-02-21
Duality of interest Contribution statement Acknowledgments Introduction Rapid, cell surface-initiated steroid actions have been reported for all major groups of steroid hormones and our understanding of membrane-mediated steroid actions has progressed rapidly over the last two decades. M
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saha drug br Experimental section br Introduction NMDA recep
2024-02-21
Experimental section Introduction NMDA receptor-induced increases in AMPAR trafficking to the synaptic surface mediates changes in synaptic efficacy in a number of saha drug regions (Shi et al., 1999, Sun et al., 2005, Frenkel et al., 2006). While this process has been linked to the regulated
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br Possible complementarity of trimming
2024-02-21
Possible complementarity of trimming pathways Determining the exact pathway for the generation or destruction of MHCI peptide ligands by ERAP1 is important for our understanding of the shaping of the immunopeptidome and for designing inhibitors that can manipulate it. It is also possible however
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With regard to the correlation
2024-02-21
With regard to the correlation between -rearrangements and thromboembolic events, Zer et al. reported a VTE rate of 36% in a cohort of 98 patients with ALK-positive NSCLC. Of note, VTE was also associated with shorter overall survival (HR: 5.71, =0.01) . Only few others have investigated NSCLC drive
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Therefore to better understand the functional
2024-02-21
Therefore, to better understand the functional properties of Peruvian infusion tea plants and provide evidence for the development of functional food supplements containing the Peruvian infusion tea plant, the aldose reductase inhibition together with the antioxidant activities of 24 selected Peruvi
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The present work has implications for our thinking about
2024-02-21
The present work has implications for our thinking about the effects of antidepressant (e.g. SSRIs) use on maternal care in depressed mothers which consist of approximately 10–20% of all mothers (Gjerdingen and Yawn, 2007, Susser et al., 2016), and more than 40% of depressed mothers are prescribed w
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The relatively high concentration of HT
2024-02-21
The relatively high concentration of 5-HT used in this study (100 µM) is consistent with the concentrations used in other published ex vivo studies (Ropert and Guy, 1991, Passani et al., 1994, Shen and Andrade, 1998). In our paradigm 5-HT was focally applied at the surface of the slice via a fast pe
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The synthesis of compounds in
2024-02-21
The synthesis of compounds in which the ethyl linker has been modified to the carbamate and urea derivatives , and is shown in . Thus the diamine was reacted with glycolic 2211 to give the alcohol followed by Mitsunobu reaction with phthalimide to give . Deprotection with hydrazine gave the amine wh
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From an historical perspective ligands
2024-02-21
From an historical perspective, ligands for GPCRs (adrenaline, serotonin, NSC23766 or morphine, to name a few) have been identified before their receptor counterparts, at a time when the concept of receptor itself was controversial [15]. Although many cognate receptors for endogenous ligands were r
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It is reported that calpain plays
2024-02-21
It is reported that calpain-2 plays a critical role in BDNF-induced signaling and memory formation, and knockdown of calpain-2, but not calpain-1, completely suppresses BDNF-induced pathway activation and protein translation (Briz et al., 2013). BDNF prevents neuronal apoptosis or death (Ferrer et a
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Kim et al found that hydroxydopamine OHDA
2024-02-20
Kim et al. (2013) found that 6-hydroxydopamine (6-OHDA) promoted the atrophy of dopaminergic neurons associated with the activation of poly (ADP-ribose) polymerase (PARP), the translocation of apoptosis inductor factor (AIF) and the depletion of ATP. An increase in p-AMPK and pS6K (upstream kinase o
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