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Regarding progression free survival analyzing clinical
2023-04-21
Regarding progression free-survival, analyzing 12 clinical trials, we demonstrated that the use of antiangiogenic treatment results in a statistically longer PFS with a pooled HR of 0.76 (95% CI 0.65–0.89, pTasquinimod receptor of improvement of PFS only is that after antiangiogenic therapy gliobla
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Incubation of the aortic segments of rats with
2023-04-21
Incubation of the aortic segments of rats with indomethacin significantly decreased the vasoconstrictor response to Phe but only in HgCl2-treated group (Fig. 9A,B), as indicated by dAUC values (Fig. 9E). Co-treatment with losartan once again proved to be effective and prevented the increased partici
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In addition enhanced AT receptor function
2023-04-21
In addition, enhanced AT1 receptor function abnormally increases central and sympathetic activity, contributing to cardiac and renal disease, which in turn alters homeostasis, increases vulnerability to stress, and further injures the brain, and that AT1 receptor blockade ameliorates excessive sympa
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The specific mechanism and neurotoxic A species are yet
2023-04-21
The specific mechanism and neurotoxic Aβ 1-Oleoyl lysophosphatidic acid sodium salt are yet to be elucidated, however recent studies have provided significant evidence for the amyloid channel hypothesis. These reports have established that relatively small oligomers ( Conflict of interest Ackno
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br Conclusions Extract of non germinated winter
2023-04-21
Conclusions Extract of non-germinated winter rape seeds cv. Bellevue was screened for the aminopeptidase activity. It revealed broad substrate specificity, with the highest activity toward Phe-pNA. Also in the partially purified sample, phenylalanine was preferentially hydrolysed. PMSF, known ser
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Neural progenitor cells NPCs are self
2023-04-21
Neural progenitor cells (NPCs) are self-renewing, multipotent cells that are capable of differentiating into neurons, astrocytes and oligodendrocytes. NPCs are activated in response to a variety of pathological states in neurodegenerative diseases such as Parkinson’s disease and multiple sclerosis,
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br Conclusion br Conflicts of Interest Disclosures br
2023-04-20
Conclusion Conflicts of Interest/Disclosures Acknowledgement This study was funded by the Ministry of Science of the Republic of Serbia (grant #175083). Introduction Myasthenia gravis (MG) is an antibody-mediated, neuromuscular transmission disorder, where the targets are postsynaptic p
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br Acknowledgments We thank the
2023-04-20
Acknowledgments We thank the anonymous reviewers for their constructive comments on the manuscript, and also thank Dr. Hans-U. Dahms for his comments on the manuscript. This work was supported by a grant from the National Research Foundation (2009-0071218) funded to Young-Mi Lee. This work was al
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The indirect effect of corporate
2023-04-20
The indirect effect of corporate taxation, as given by the second term in Eq. (18), consists of two elements; (i) a standard euk 134 effect (τ/n2), and (ii) a capital cost effect (rG(1−αt)/(1−t)). With a CRS technology, the cost effect vanishes, whereas with an IRS (a DRS) technology the cost effec
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br Disclosure br Acknowledgement br Introduction CYP
2023-04-20
Disclosure Acknowledgement Introduction CYP17A1 is a multifunctional enzyme with both 17α-hydroxylase and 17,20-lyase activities and is essential for the biosynthesis of steroidal lobeline in male testes and adrenal glands. The 17α-hydroxylase activity of CYP17A1 is involved in the convers
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Renal Cell Carcinoma RCC is a lethal cancer with bad
2023-04-20
Renal Cell Carcinoma (RCC) is a lethal cancer with bad prognosis due to development of chemoresistance and recurrence of an aggressive tumor with increased tumor-angiogenesis and metastasis [7]. We have found Axl and Gas6 to be differentially presented in RCC subtypes, and Axl to correlate to tumor
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A large number of studies have shown that oxidative
2023-04-20
A large number of studies have shown that oxidative stress is involved in the pathophysiological process of ventricular remodeling and is associated with left ventricular dysfunction (Hori and Nishida, 2009, Lord et al., 2010). The generation of reactive oxygen species (ROS) that exceeds anti-oxidat
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br In vivo visualization of aromatase with
2023-04-20
In vivo visualization of aromatase with positron emission tomography (PET) Positron emission tomography (PET) utilizes the high JP 1302 dihydrochloride photons formed during the annihilation of positrons to detect the changes in the amount and localization of injected radiopharmaceuticals in the
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Previously we have detected the expression of APJ receptor
2023-04-20
Previously, we have detected the expression of APJ receptor on stomach projecting AZ3146 in DMV, in addition, icv administration of apelin-13 induced a remarkable c-Fos activation in those cells which were previously marked by a retrograde neuronal tracer fast blue (Birsen et al., 2016). Moreover,
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It has been proven that genetic polymorphisms can play an
2023-04-20
It has been proven that genetic polymorphisms can play an important role in development of hypertension and CVDs. In a Turkish population-based study, it was found that the APLNR gene (rs948847-A445C) polymorphism was not associated with coronary artery disease (CAD), but it was shown to be related
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