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We have previously shown that the
2023-01-30
We have previously shown that the human gonadotropins hLH and hCG trigger a partly irreversible stimulation of intracellular cyclic AMP accumulation in mouse Leydig Tumor soluble guanylate cyclase (MLTC) in contrast to all other tested mammalian LHs and CG (Klett et al., 2016). In order to get a be
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Mast cells Mast cells are
2023-01-30
Mast cells. Mast Apoptozole are immune cells of the myeloid lineage and are ubiquitously present in connective tissues [75]. These cells are involved in the modulation of a number of physiological functions, such as vasodilation, angiogenesis, bacterial, and parasite elimination [75]. Moreover, mas
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h89 Regarding A Rs and A ARs
2023-01-30
Regarding A1Rs and A2ARs, basal conditions generate a low tone of endogenous adenosine and cause A1R activation, in contrast to situations of increased adenosine where A2AR activation becomes dominant. When adenosine concentrations rise, e.g. during hypoxia, also time appears likely important in reg
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Previous reports indicate that the expression of AChRs and
2023-01-30
Previous reports indicate that the expression of AChRs and their clustering on myotubes are critical factors required to induce contacts on muscle fibers in a natural biological system [14], [15], [16], [17], [18], [19]. For instance, in NMJ development in the mouse, AChRs are pre-patterned at sites
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Although the mechanisms of APP secretion are well characteri
2023-01-30
Although the mechanisms of APP secretion are well characterised (for review see Ref. [1]), production of soluble AChE species is less well understood although we have reported that a metalloproteinase can shed AChE similarly to APP [16], [17]. Recently it has also been demonstrated that cellular pre
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The SKOV and SKOV TR cells were exposed
2023-01-30
The SKOV3 and SKOV3TR GS-9973 were exposed to stepwise increased concentration of paclitaxel with or without a different concentration of autophagy inhibitor (3-MA or HCQ) to further evaluate whether suppression of autophagy affected the growth and drug sensitivity of ovarian cancer cells in vitro.
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br Materials and methods br Results br Discussion
2023-01-30
Materials and methods Results Discussion Numerous studies showed that Na+-K+-ATPase activity and membrane Tigecycline were decreased in cardiac tissue subjected to IR (Belliard et al., 2013; Lee et al., 2013). In return, treatment that alleviated the progress of IR-related myocardial injur
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Most of lipid lowering agents have many therapeutic problems
2023-01-30
Most of lipid-lowering agents have many therapeutic problems with severe side effects, while dietary fibers as lipid lowering therapy are safer. Chitosan (CS) is a dietary fiber biodegradable, biocompatible and has many health benefits including wound healing, antiinflammatory, anti-cancers, immune-
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Although the earlier studies focused on the antioxidant capa
2023-01-30
Although the earlier studies focused on the antioxidant capacity of tocopherols, ascorbic CRT 0066101 and carotenoids, then it was noticed that phenolic compounds were more powerful than others (Rice-Evans, Miller, & Paganga, 1996). Phenolic compounds, the most numerous and ubiquitous groups of pla
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MT SGL encourages a individual feature selection
2023-01-29
MT-SGL encourages (a) individual feature selection based on the utility of the features across all tasks with ℓ2,1-norm and (b) task specific group selection based on the utility of the group with G2,1-norm, i.e., Exo1 regions of interest (ROI) for that task. Unlike basic SGL for regression (Chatte
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For patients who have taken advantage
2023-01-29
For patients who have taken advantage of the anti-TKIs and whose follow-up has been succeeded, some partial response has been noticed with 45% (9/20) for gefitinib, 39% (9/23) for erlotinib and 56.5% (13/23) for crizotinib. A disease progression has also been observed with 35% (7/20) for gefitinib,
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HsALDH enzyme has been purified for the first
2023-01-29
HsALDH enzyme has been purified for the first time in our laboratory from human saliva and has been kinetically characterized using different aromatic substrates [35]. Also, the effect of some common substances frequently encountered by the enzyme in the oral cavity (such as ethanol, hydrogen peroxi
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Within the PARP family TIPARP
2023-01-29
Within the PARP family, TIPARP is most evolutionarily conserved with PARP12 (ARTD12) and PARP13 (ARTD13) [27,28,41]. All three proteins contain at least one RNA-type CCCH zinc finger domain, a poly-ADP-ribose binding WWE domain and a PARP catalytic domain (Fig. 1). PARP13 is catalytically inactive,
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br Adenosine receptors and the
2023-01-29
Adenosine receptors and the adaptive immunity T lymphocytes are responsible for the cell-mediated immune response [95]. These cells can be stimulated by the presentation of antigenic moieties by APCs, such as dendritic cells or macrophages [96]. The presentation of antigenic molecules on the APC
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While the yeasts and see Glossary
2023-01-29
While the yeasts and (see Glossary) each contain only one Aurora homolog, Ipl1p (increase in ploidy 1) and Ark1 (Aurora-related kinase 1), respectively 5, 6, , and Xenopus laevis contain two Aurora kinases: Aurora A and Aurora B [4]. Mammals have three Aurora kinases, A, B, and C (Figure 1). In anim
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