• On the basis of the structure of

  2022-07-08

  

  On the basis of the structure of the Rab35/ACAP2 complex, the authors identified Thr76 in switch II of Rab35 as one key specificity determinant (Lin et al., 2019). The crystal structure shows that the hydroxyl group of Thr76 forms a Quinacrine hydrochloride hydrate with Asp756 in ACAP2, while the m

• Similar to GPR A activation of G

  2022-07-08

  

  Similar to GPR109A, activation of G-protein-coupled receptor 81 (GPR81, also called HCAR1 (hydroxycarboxylic Superoxide Dismutase (SOD) Activity Assay Kit receptor receptor 1)) by lactate suppresses lipolysis (Fig. 1), suggesting GPR81 to be a potential drug target for treating T2DM (Boyd et al., 1

• Recently higher grade varicoceles have been reported to be

  2022-07-08

  

  Recently, higher-grade varicoceles have been reported to be associated with higher nocturia levels [20], and we observed an interesting phenomenon in which the urine volume/water intake ratio dramatically increased in the rat model of experimental left varicocele (ELV); the decreases in hypothalamic

• The aim of our study was to investigate the

  2022-07-08

  

  The aim of our study was to investigate the polymorphisms of RAGE and glyoxalase I gene and sRAGE serum levels in patients with pathological pregnancy trying to describe the genetic background of pathological pregnancy or to find a new biochemical marker (sRAGE) of these pathological states in pregn

• br Introduction Cherry tomato Solanum lycopersicum L is

  2022-07-08

  

  Introduction Cherry tomato (Solanum lycopersicum L.) is a commonly consumed fruit on a worldwide scale due to its characteristic flavor and high nutrition (Wei et al., 2016, Yu et al., 2014). Tomato is low in fat and calories, and is a rich natural source of nutrition and bioactive antioxidant co

• Peripheral injury or disease induced alterations in synaptic

  2022-07-08

  

  Peripheral injury- or disease-induced alterations in synaptic efficacy occur not only at the first synapse made by the primary nociceptive afferents in the spinal dorsal horn but are also operational in several regions processing the sensorimotor as well as emotional-affective components of pain, su

• In order to test the influence of the initial depolarization

  2022-07-07

  

  In order to test the influence of the initial depolarization, experiments were performed, where the degree of chloride substitution was varied, either by adding n-Ringer to cantharidin synthesis incubated in a sucrose Ringer or by suspending the cells directly in Ringers identical to the final comp

• The knowledge that piroxicam competes with ligands that bind

  2022-07-07

  

  The knowledge that piroxicam competes with ligands that bind to FPR may be of importance for a deeper understanding of the anti-inflammatory effects possessed by this NSAIDs. It has recently been reported that not only phagocytes but also platelets express FPR on their cell surface and that these re

• Studies have revealed that ferroptosis

  2022-07-07

  

  Studies have revealed that ferroptosis is non-apoptotic and peroxidation-driven form of cell death that requires abundant and accessible cellular Fe2+, and thus, the balance of Fe2+ metabolism is of great significance in regulating the process of ferroptosis (Cao and Dixon, 2016; Xie et al., 2016; Y

• We have presented evidence that

  2022-07-07

  

  We have presented evidence that only muscle FBPase is detectable within HL-1 cells. This is consistent with past findings of the Eschrich's group, which showed that in rat heart Acyclovir expression of FBPase is almost exclusively limited to the muscle isozyme [3]. Results of our preliminary exper

• Compounds and were evaluated for

  2022-07-06

  

  Compounds and were evaluated for their pharmacokinetic properties in rats and the results are summarized in . Following intravenous (IV) administration, both compounds displayed low clearance (CL), short half-lives (t) and low volumes of distribution (V). When dosed orally as a solution, exposure

• We also evaluated the effect of varying ionic str http

  2022-07-06

  

  We also evaluated the effect of varying ionic strength. These experiments included previously characterized H3 (residues 1–21) and SNAIL (residues 1–9) peptides [8], [34] to allow a comparative analysis with different ligands (Fig. 1A). As shown in Fig. 2 and listed in Table 2, it is evident that a

• Bile acids are the end products of

  2022-07-06

  

  Bile acids are the end products of cholesterol catabolism and have also been considered as hepatomitogens. Recently, Yap has been shown to be activated by the mevalonate pathway, which is essential for the biosynthesis of isoprenoids and downstream cholesterol and bile acids (Sorrentino et al., 2014

• We are pursuing a hit to lead medicinal

  2022-07-06

  

  We are pursuing a hit-to-lead medicinal chemistry campaign to optimize inhibitors of the HBV RNaseH. Here, we report the activity of seven new HIDs and nine new HPDs, with significant improvements in in vitro potency and cytotoxicity profiles for the HPD compounds. Materials and methods Result

• Here we report the genomic structure and the

  2022-07-06

  

  Here we report the genomic structure and the phylogenetic analysis of testis-specific Ser/Thr kinase haspin gene. Materials and methods Results Discussion The isolation and analysis of haspin genomic DNA showed that haspin was an intron-less gene and localized in an intron of integrin αM29

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