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Sumoylation of transcription factors has been generally link
2022-04-01
Sumoylation of transcription factors has been generally linked to transcriptional repression and, in a few cases, to transcriptional activation [60] Accumulating evidence implies that corepressor complex subunits, including CoREST, CtBP, Daxx, NCoR1, SMRT and histone deacetylase complexes (HDACs), p
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Overall while cART has significantly prolonged life and amel
2022-04-01
Overall, while cART has significantly prolonged life and ameliorated HIV-associated disease, HIV infection of the CNS still induces a number of cognitive, behavioral and motor symptoms, along with substantial neuropathology. Data show that the inflammatory processes driving neurological disease pers
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In Arabidopsis GCN containing protein complexes
2022-03-31
In Arabidopsis, GCN5-containing protein complexes are found to be involved in cell differentiation, leaf and floral organogenesis [[8], [9], [10]]. AtHAC1 has involvement with root elongation, flowering, fertility and de novo shoot regeneration [11,12]. AtHAM1 and AtHAM2 control flowering time by ep
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br Materials and methods br Results Heterologous
2022-03-31
Materials and methods Results Heterologous expression of P. locustae Hxk in methylotrophic yeast P. pastoris was not accompanied by nuclear localization of parasite protein (Fig. 1). The addition of leptomycin B, a specific inhibitor of nuclear export in fission yeast Schizosaccharomyces pombe
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Curcumin is a major yellow
2022-03-31
Curcumin is a major yellow pigment in turmeric ground rhizome of Curcuma longa Linn, which is used widely as a spice and coloring agent in several foods such as curry, mustard and potato chips as well as cosmetics and drugs (Okada et al., 2001, Joe et al., 2004). Curcumin represents a class of anti-
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Previous studies have established that phosphorylation of GC
2022-03-31
Previous studies have established that phosphorylation of GC-B is required for activation of GC-B. Conversion of all six chemically determined serine and threonine phosphorylation sites in GC-B to alanines produced a properly folded enzyme that retained GC activity under synthetic detergent activati
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The frequency of GSTM and
2022-03-31
The frequency of GSTM1 and GSTT1 null genotypes vary in different populations. For example, Hiragi et al. (2007) reported a frequency of 17–35% for the GSTM1 null genotype and 22–44% for the GSTT1 null genotype in Brazilians of African descent (Hiragi et al., 2007). Chen, Liu, and Relling (1996) rep
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The observed glucose intolerance and elevated fasting
2022-03-31
The observed glucose intolerance and elevated fasting blood glucose in this study is in consonance with earlier study (Ferris and Kahn, 2012). These have been the common features of GC exposure and are not unexpected. Previous researches that reported IR during GC exposure have shown controversy con
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Molecular mechanisms of decidualization have been studied fo
2022-03-31
Molecular mechanisms of decidualization have been studied for years, revealing numerous signaling pathways and transcriptional factors participated in the regulation [37,38]. As a central controller of deicdualization, FOXO1 regulates the transcription of a large number of target genes, which are in
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One clue to how evolution has solved such
2022-03-31
One clue to how evolution has solved such spatiotemporal challenges comes from studies revealing that lymph node (LN) organization is more complex than originally presumed, suggesting that steady-state microanatomical features are crucial for effective immune responses (reviewed by Qi et al., 2014).
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br Methods br Results br Discussion LPD
2022-03-31
Methods Results Discussion LPD, in terms of insufficient secretion of progesterone by the CL, reflected by low serum progesterone levels can occur in IVF attempts using any kind of ovarian stimulation protocol (Fatemi et al., 2007, Garcia et al., 1981, Van der Linden et al., 2011). However,
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In summary we discovered azaindole substituted hydroxypyrido
2022-03-31
In summary, we discovered 7-azaindole substituted -hydroxypyridone as a potent zinc-binding GLO1 inhibitor (IC=11nM) through lead generation from HTS and structure-based inhibitor design. The X-ray cocrystal structure and the comparison of binding energies with the indole counterpart revealed that
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To further investigate its role in stresses tolerance OsGly
2022-03-31
To further investigate its role in stresses tolerance, OsGly I was overexpressed in transgenic rice. qRT-PCR and zymologic determination showed that R788 disodium level of OsGly I and the glyoxalase I activity were significantly increased to different extent in the transgenic overexpression lines (
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THZ531 Here we reported series of
2022-03-31
Here, we reported series of carbohydrate-modified compounds containing a dibromo substituted benzene ring which was derived from the red alga (). The conformation flexibility of THZ531 and their polyol structures give them many unique biological properties as we have described earlier. More interest
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Ionotropic glutamate receptors GluRs are ligand gated ion
2022-03-31
Ionotropic glutamate receptors (GluRs) are ligand-gated ion channels that mediate information processing at the majority of excitatory synapses in the brain and participate in such physiological processes as learning and memory, development and maintenance of cellular connections, and pain perceptio
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