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Alpha SYN has no direct effect on forskolin induced
2021-08-18
Alpha-SYN has no direct effect on forskolin-induced CREB phosphorylation, but rather blocks the stimulation of CRE-mediated transcription in the nucleus. Previously we suggested that α-SYN can enter the nucleus and is present in both cytosolic and nuclear fractions without direct interaction between
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Furthermore Survivin is a member of the
2021-08-18
Furthermore, Survivin is a member of the inhibitor of apoptosis family. IR induces a rapid nuclear accumulation of survivin and subsequent phosphorylation of the protein in the nucleus. Co-immunoprecipitation and immunofluorescence co-localization analyses revealed an interaction among survivin, Ku7
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Although DGK is a lipid modulating enzyme
2021-08-18
Although DGKγ is a lipid-modulating enzyme, the role of DGKγ in integral cell metabolism has not been reported. We found that DGKγ made a difference on cell metabolism profile in HCC cells, which may be caused partially by the downregulation of GLUT1. Glucose is a major source of energy, and decreas
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br Conflicts of interest br Introduction Diacylglycerols
2021-08-18
Conflicts of interest Introduction Diacylglycerols (DAGs) and phosphatidic Z-YVAD-FMK synthesis (PA) play fundamental roles in biology as basic components of membranes, intermediates in lipid metabolism, and secondary messengers in cellular signaling (Carrasco and Merida, 2007, Fang et al., 20
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The use of AACSB accreditation as an indicator of
2021-08-17
The use of AACSB accreditation as an indicator of expected performance on the CPA exam has been examined by prior studies (e.g. Barilla et al., 2008, Boone et al., 2006, Grant et al., 2002, Howell and Heshizer, 2006, Lindsay and Campbell, 2003, Marts et al., 1998). While these studies are based on d
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Meanwhile high levels of extraversion have
2021-08-17
Meanwhile, high levels of extraversion have been associated with weaker conditioning and faster kanamycin sulfate australia learning (Eysenck, 1970). Similar to neuroticism/anxiety, the role of extraversion for fear conditioning and extinction has found only limited empirical support (Rauch et al.,
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read the article Our results for imidacloprid were unexpecte
2021-08-17
Our results for imidacloprid were unexpected: considering that imidacloprid (Im) is a neonicotinoid insecticide with a different mode of action (agonist of the nicotinic read the article receptor) than OPs, we expected Es-ChE and T-ChE activity to be largely insensitive to changes in Im concentratio
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Mohan et al found no improvement of the strength
2021-08-17
Mohan et al. [8] found no improvement of the strength of the bricks due to addition of waste RHA. Hossain et al. [9] collected RHA from a local rice mill, where rice husk was burnt in an uncontrolled environment, and then used for replacement of clay in brick production. With inclusion of RHA water
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br Results br Discussion We first tested for any
2021-08-17
Results Discussion We first tested for any adverse effect of ATR on learning and memory with a MWM test, which is used to assess hippocampal spatial learning and memory abilities in rodents (Vorhees and Williams, 2006). In the place navigation test, the escape latency – or time spent locating
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br Funding This work was supported by intramural funding of
2021-08-17
Funding This work was supported by intramural funding of the Department of Internal Medicine I-Cardiology, University Hospital Aachen, RWTH Aachen. Acknowledgments Introduction Cyclic adenosine monophosphate (cAMP) is a central second messenger that controls a plethora of vital functions.
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Several studies highlighted the potential of
2021-08-17
Several studies highlighted the potential of EOCs to promote adverse effects on aquatic organisms. It was reported the toxicity of BPA to invertebrates and fish, and the effect of lipophilicity on toxicity was analyzed (Mathieu-Denoncourt et al., 2016). There was reported the effects of PPCPs on aqu
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Recent reports revealed that CSE affects the
2021-08-17
Recent reports revealed that CSE affects the endothelial cells of various tissues like kidney, liver, heart including antibiotics [26,30]. The damage of brain endothelial cells enhances the progress of cognitive dysfunction due to the accumulation of toxic free bio-radicals and activation of inflam
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br Acknowledgments The authors acknowledge
2021-08-17
Acknowledgments The authors acknowledge funding from the National Key Research and Development Program of China (2016YFA0502900) and the National Science Foundation of China (31570188). Compartment Size Regulation Regulation of compartment size is one of the most fundamental issues in biology
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The totality of evidence from randomized clinical trials sup
2021-08-17
The totality of evidence from randomized clinical trials supports the premise that worsening 9292 sale failure is a class effect of DPP-4 inhibitors. A meta-analysis by Verma et al. (54) of 100 randomized controlled clinical trials reported that the use of DPP-4 inhibitors was accompanied a signifi
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Our ex vivo analysis demonstrates that IL
2021-08-16
Our ex vivo analysis demonstrates that IL-15 promotes CD122 expression in DGKζ-deficient CD8+ T cells. CD122, which forms a dimer with CD132 in response to IL-2 or IL-15, activates the JAK/STAT and PI3K/mTOR pathways. Whereas antigen-stimulated Ginsenoside Rb1 promote IL-2 sensitivity through up-reg
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