• Application of the broad acting HTR antagonist methiothepin

  2024-09-03

  

  Application of the broad-acting 5-HTR antagonist methiothepin (Bard et al., 1996, Hoyer et al., 1994, Peroutka, 1990) converted the TBS-induced response of both thalamocortical and intracortical A1 synapses from LTP to LTD, an effect that was mimicked by the selective 5-HT2R antagonist ketanserin (L

• Evaluation of plant growth Transgenic Arabidopsis plants

  2024-09-03

  

  Evaluation of plant growth. Transgenic Arabidopsis plants were examined by microscope for alterations in cell size and shape. Overall plant architecture was also compared with control plants. Results and discussion Acknowledgments Introduction Mammalian ACK1 is a kinase effector for Cdc42

• (+)-Apogossypol The UV vis and fluorescence spectra have bee

  2024-09-03

  

  The UV–vis and fluorescence spectra have been used to study the interaction between small chemical molecules and biomolecules (Punith and Seetharamappa, 2012). The UV (+)-Apogossypol peak of the protein changes with the microenvironment of the chromophore. That is, the peaks may show a certain degr

• Introduction hydroxytryptamine HT is found throughout the bo

  2024-09-03

  

  Introduction 5-hydroxytryptamine (5-HT) is found throughout the body and influences smooth muscle activity in various tissues including the intestine, vasculature and urinary SIN-1 chloride (Kim and Camilleri, 2000, Klarskov and Horby-Petersen, 1986, Mohammad-Zadeh et al., 2008). The current class

• sodium butyrate Axl which belongs to the Tyro Axl Mer

  2024-09-03

  

  Axl, which belongs to the Tyro-Axl-Mer (TAM) family of RTKs, has been reported to regulate a variety of physiological processes including cell survival, proliferation, migration and adhesion, through the activation of the phosphoinositide 3-kinase (PI3K)/V-akt murine thymoma viral oncogene homolog (

• Fencilli et al reported derivatives of PHA which

  2024-09-03

  

  Fencilli et al. reported derivatives of PHA-680626 (15) which demonstrated strong anti-proliferative activity against large group of leukaemia cell lines including IM-resistant BAF3 cells expressing mutants like T315I, M351T and E255K. Decrease in Histone H3 phosphorylation led to induction of endo-

• We also measured macrophage infiltration and

  2024-09-03

  

  We also measured macrophage infiltration and CLS presence in peri-gonadal AT from db/db mice and controls. CLS are morphological features within AT that are accurate indicators of adipocyte death and macrophage infiltration [56]. An earlier study showed that CLS macrophages account for >90% of the t

• The mitogen activated protein kinase MAPK

  2024-09-03

  

  The mitogen-activated protein kinase (MAPK) plays an important role in a variety of cell processes by controlling transcriptional or translational regulation [14]. There are three major MAPK family members that have been well characterized: extracellular signal-regulated kinase (ERK), c-Jun N-termin

• TLRs play a key role in pathogen recognition

  2024-09-02

  

  TLRs play a key role in pathogen recognition and early response. In our study, we showed an increase of TLR2 mRNA and protein expression after BMECs were stimulated by S. aureus, as seen for BMECs in a previous study [25]. Although most studies describe TLR4 as a primary receptor for Gram-negative b

• br Results Four HT esters

  2024-09-02

  

  Results Four HT esters (butyrate, caprylate, laurate and stearate esters) were chosen as representative compounds of increasing lipophilicity (Fig. 1). We will refer to them as C4HT, C8HT, C12HT and C18HT, respectively. They have been synthesized, purified and characterized according to our previ

• We conclude that Tetrapleura tetraptera fruits extract posse

  2024-09-02

  

  We conclude that Tetrapleura tetraptera fruits extract possess antiplasmodial activity and the results of this study justifies and confirms the traditional usage of this plant as malarial remedy. Acknowledgement Introduction The phylum apicomplexa comprises of nearly 5000 species, most of whi

• Glycosylphosphatidylinositol GPI cell wall anchor synthesis

  2024-09-02

  

  Glycosylphosphatidylinositol (GPI) wdr5 anchor synthesis pathway is another promising antifungal target. Novel inhibitors of Gwt1 and Mcd4, two enzymes in the GPI anchor pathway were identified by the chemical-genomics-based screening platform CaFT (Candida albicans fitness test) [89]. Screening wa

• The radiographic correlate will be similarly important for

  2024-09-02

  

  The radiographic correlate will be similarly important for the success of other non-VEGF TKIs, such as those targeting the epidermal growth factor receptor expressed in 50% of high-grade primary caspofungin synthesis neoplasms. It has been reported that icotinib and gefitinib, epidermal growth facto

• The radiographic correlate will be similarly important for

  2024-09-02

  

  The radiographic correlate will be similarly important for the success of other non-VEGF TKIs, such as those targeting the epidermal growth factor receptor expressed in 50% of high-grade primary acetylcholine receptor neoplasms. It has been reported that icotinib and gefitinib, epidermal growth fact

• OR-486 synthesis br Eprosartan The AT R

  2024-09-02

  

  Eprosartan The AT1R antagonist eprosartan is approved for the treatment of essential OR-486 synthesis and may be administered using a convenient once-daily regimen. The drug is a well-tolerated and effective antihypertensive agent with benefit in the secondary prevention of cerebrovascular event

13960 records 54/931 page Previous Next First page 上5页 5152535455 下5页 Last page