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At this stage it is still difficult
2021-04-20
At this stage it is still difficult to assign specific domains to some of the regions observed in these structures, although some attempts have already been made (Brewerton et al., 2004). Clearly, higher resolution data is needed. In the future, even if an atomic structure of DNA-PKcs is determined,
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To determine whether the same concentration of humic acid
2021-04-20
To determine whether the same concentration of humic histamine-1 receptor antagonist causes changes in PCR efficiency, we performed another experiment in which the humic acid was added to the PCR mix after bisulfite conversion. All samples that were amplified in the presence of humic acid (thick li
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PF-543 As DNA methylation plays a critical role
2021-04-20
As DNA methylation plays a critical role in organismic development and human diseases, the interest in DNA methyltransferases is constantly increasing. Extensive studies on the repertoires of dnmts genes have indicated increasing dnmts members in eukaryotes (Goll and Bestor, 2005; Ponger and Li, 200
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Talarozole We recently reported that the information
2021-04-20
We recently reported that the information about the electronic density obtained from a QTAIM analysis is useful to describe the molecular interactions that stabilize and destabilize the different complexes L-R [13], [14], [15]. Specifically in our previous work reported for DHFR inhibitors, the QTAI
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It has been reported that vernolic acid
2021-04-20
It has been reported that vernolic RO4987655 accumulation in transgenic Arabidopsis seeds expressing a Δ12-epoxygenase often resulted in failure of germination and impaired growth and development (Singh et al., 2001). Similar phenomena were also reported for transgenic Arabidopsis seeds with accumu
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Natural and synthetic glucocorticoids perform their biologic
2021-04-20
Natural and synthetic glucocorticoids perform their biological action in the organism through receptor-dependent mechanisms (e.g., by binding to the glucocorticoid receptors). It has been determined that glucocorticoid receptors cross-talk with other nuclear receptors, including AhR (Celander et al.
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The cyclin dependent kinase deactivation is carried out by
2021-04-20
The cyclin-dependent kinase deactivation is carried out by a particular group of proteins cyclin-dependent kinase inhibitors (CDKIs). These group of proteins blocks kinase activity by interfering with the interaction of cyclin-CDK complex [43]. The inhibition of CDK naturally occurs during a G1 phas
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Previous studies reported that NE and
2021-04-20
Previous studies reported that NE and MHPG are deeply involved in depression and that NE reuptake inhibitors are approved for use in patients with depression (for review, see [2]). We found increased hippocampal content of NE and MHPG in the CORT-treated CRTH2−/− mice (Fig. 3). In the hippocampus, a
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Three dimensional conformational changes in the
2021-04-20
Three-dimensional conformational changes in the cargo protein’s NES, caused by protein phosphorylation, dephosphorylation, or mutation, can regulate CRM1 binding (Craig et al., 2002, Vogt et al., 2005). Additional protein modifications such as sumoylation, ubiquitination, acetylation, and/or the bin
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phorbol myristate acetate br Acknowledgements This work was
2021-04-19
Acknowledgements This work was supported by the European Committee Fifth Framework Project QLK5-1999-01360. We are grateful to Dr. T.T. Hoang for the provision of plasmids pEX18Tc, pPS858 and pFLP2, Prof. B.L. Wanner for providing us with the plasmid pKD4 and related strains, and Prof. P. Soucail
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Sensory gating describes a filter
2021-04-19
‘Sensory gating’ describes a filter mechanism protecting the central nervous system from sensory overload by inhibiting behaviorally irrelevant input (Boutros et al., 2004, 2008). This permits EPZ031686 to a changing contextual environment (Fruhstorfer et al., 1970; Grunwald et al., 2003). Auditory
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GSK1278863 br Patients and methods br Results Table
2021-04-19
Patients and methods Results Table 1 shows relevant demographic and clinical characteristics of the 123 patients in the cohort. BAL fluid samples were obtained at a median of 172.5 days after allo-HSCT (range 3 days to five years). Discussion The definitive abandonment of traditional cultu
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Analysis of DNA fragmentation We followed a modified
2021-04-19
Analysis of DNA fragmentation. We followed a modified Hirt extraction procedure for analysis of DNA fragmentation. Cells were suspended in TNE buffer (1M NaCl, 20mM Tris–HCl, pH 7.4, 2mM EDTA, and 0.6% SDS) at a density of 106 cells/ml and incubated overnight on ice. The next day, cellular debris wa
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It is common for plants that are deficient
2021-04-19
It is common for plants that are deficient in P to invest in their roots in order to maximise P uptake from the soil. Here, plants grown in soil amended with OA had a higher root biomass:shoot Retapamulin ratio compared with plants in the INORG-P treatment. Additionally, greater allocation of C to
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br Materials and methods br
2021-04-19
Materials and methods Results Discussion In this study, we confirmed the activation of Akt by udenafil in 3T3-L1 cells. To elucidate the underlying mechanism of udenafil, we focused on the mitochondria. Our findings demonstrated that udenafil improved mitochondrial function and expression o
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