• If the factors needed for A NHEJ are not

  2020-08-11

  

  If the factors needed for A-NHEJ are not completely defined and the A-NHEJ reaction mechanism nebulous, it is also fair to say that the biological role(s) of A-NHEJ is even more poorly understood. Most of the current interest in A-NHEJ, however, stems from its implicated use in the chromosomal trans

• The folate pathway plays an essential role in

  2020-08-11

  

  The folate pathway plays an essential role in cell survival by generating 5, 10-methylene tetrahydrofolate as a one-carbon donor for the synthesis of deoxythymidine monophosphate (dTMP), purines, methionine and histidine. Disruption of this pathway leads to the critical deficiency of these key molec

• For LAU extracted ion chromatograms of the blank

  2020-08-11

  

  For LAU 399, extracted PSB 1115 chromatograms of the blank, t0, and t120 samples for the diagnostic product ion m/z 163.0216 are provided in Fig. S11, and extracted ion chromatograms of the t120 sample for m/z 163.0216 (diagnostic product ion), and m/z 308.1677 and 306.1522 (metabolites) are shown

• br Making the BN Cox model

  2020-08-11

  

  Making the BN-Cox model computationally efficient One of the challenges to applying the BN-Cox model is an exponential growth of the conditional probability tables (CPT) corresponding to the survival variables, as the number of risk factors increases [22]. When the number of risk factors is high,

• Importantly piPolB holds a great

  2020-08-10

  

  Importantly, piPolB holds a great promise for developing novel biotechnological applications. For instance, in vitro activities of piPolB, namely, strand displacement and faithful, processive DNA polymerization, can be harnessed for efficient primer-independent whole-genome amplification, whereas th

• p is a tumor suppressor gene that inhibits cyclin dependent

  2020-08-10

  

  p16 is a tumor-suppressor gene that inhibits cyclin-dependent kinase 4 and 6 activities and arrests the Cy5 EGFP mRNA in the G1 phase. Aberrant methylation and mutation of p16/MTS1 in OSCC of patients was found in our previous study. Moreover, the frequency of hypermethylation of p16 from the prese

• Colony stimulating factor receptor CSF R or cFMS is

  2020-08-10

  

  Colony stimulating factor-1 receptor (CSF-1R or cFMS) is a type III receptor tyrosine kinase. It is activated by binding with CSF-1 and IL-34, which stimulates differentiation, proliferation, survival and migration of monocyte-macrophage lineage cells., , , Also, macrophages produce inflammatory med

• Conversely to the reduction in restraint evoked

  2020-08-10

  

  Conversely to the reduction in restraint-evoked HR increase following the blockade of CRF receptors, Nijsen et al. [28] demonstrated that BNST treatment with a nonselective CRF Ranitidine antagonist enhanced the tachycardia evoked by contextual fear conditioning. Taken together, these results indic

• Our results show that COX and COX

  2020-08-10

  

  Our results show that COX-1 and COX-2 inhibition improve cognitive performance and decrease the neuronal insult during HH. However, when a neuroinflammatory response was observed, COX-1 inhibition was more effective than COX-2 inhibition at reducing microglial activation and augmenting pro-inflammat

• These data indicate that in the context of the

  2020-08-10

  

  These data indicate that, in the context of the N-terminal 42 amino acids of p53, threonine 18 is a substrate for phosphorylation by CK1 as mediated by prior phosphorylation of serine 15. To determine whether this is a property of full length p53, GST-p53 fusion proteins comprising the full length p

• Finally we demonstrated for the first

  2020-08-10

  

  Finally, we demonstrated for the first time that the physiological combinations of estradiol and progesterone levels of premenopausal and postmenopausal women efficiently stimulated the growth of T47D spheroids while clinically relevant concentrations of TPA and UPA suppressed the growth of T47D sph

• br Materials and methods br Results br

  2020-08-10

  

  Materials and methods Results Discussion The effect of progestogen treatment showed some tendencies affecting the body length and weight, however these data were not verifiable statistically. This observation could be explained with the relatively short exposure period and/or the relatively

• Accordingly we prepared three compounds and as shown

  2020-08-10

  

  Accordingly, we prepared three compounds (, , and ) as shown in . Condensation of commercially available no sodium salt with glycine methyl ester gave amide . A Friedel–Crafts reaction between compound and 4-methyl valeryl chloride in the presence of aluminum chloride mainly produced undesired c

• Quantifying diffusion is greatly complicated

  2020-08-10

  

  Quantifying Albendazole is greatly complicated by the ubiquitous unevenness of soil surfaces and related water films, which introduce a large uncertainty into size (area) and quality of contact between the soil surface and the membrane, the problem being particularly substantial in well aggregated

• Because sex steroids and growth hormone play

  2020-08-10

  

  Because sex steroids and growth hormone play an important role in the development and maintenance of hepatic CYP450 enzyme expression and ER expression, it is possible that exposure to endocrine active agents during gestation and perinatally could alter expression of these proteins. Therefore, these

14157 records 757/944 page Previous Next First page 上5页 756757758759760 下5页 Last page