• Several studies have shown a

  2020-08-04

  

  Several studies have shown a high degree of sequence conservation especially in the nucleic AZD 3965 binding domain, usually referred to as `cold shock domain or CSD,\' highlighting the importance of the metabolic processes regulated by Y-box proteins , , , , . A direct role for YB-1 in cell divisio

• br Materials and methods br Results br

  2020-08-04

  

  Materials and methods Results Discussion In this study, we demonstrated that, at the level of hREECs, blockade of the ETA receptor partially inhibited the effect of NPY on the secretion of ET-1. This suggests that the secreted ET-1 by NPY contributes, in part, to its own secretion via activ

• To overcome the previously mentioned limitations

  2020-08-04

  

  To overcome the previously mentioned limitations of RT-PCR and FISH, we sought to develop a next-generation sequencing (NGS)–based method for the molecular diagnosis of fusion-associated childhood sarcomas. Herein, we present a novel multiplex assay, designated ChildSeq-RNA, which combines target-ca

• The wide range of biological roles

  2020-08-04

  

  The wide range of biological roles attributed to cPLA2α has been extended by recent work implicating this enzyme in the selective production of lipid mediators during macrophage polarization to either M1 (pro-inflammatory) or M2 (anti-inflammatory) states. A recent study investigated the synthesis

• Cytosolic protein degradation is usually carefully

  2020-08-04

  

  Cytosolic protein degradation is usually carefully regulated, since uncontrolled proteolysis would be deleterious to the cell and a waste of energy. There has been no feedback regulation mechanism reported for TPP II to date. Instead, activity is proposed to be controlled by complex formation, since

• In summary we describe here two proteins that

  2020-08-04

  

  In summary, we describe here two proteins that interact with the malin–laforin complex and modulate its ubiquitination activity. These new partners again highlight a link between proteins involved in LD and autophagy. Presumably, as we propose in Fig. 9, UBE2N interacts with the malin–laforin comple

• 8602 mg To clarify the mechanism of dnmt involving in regula

  2020-08-04

  

  To clarify the mechanism of dnmt3 involving in regulating pachytene impairment of prophase I, which directly lead to sterility in 3n fish, the upstream signal and the downstream target of dnmt3 were investigated. In fertile fish, for the tiny size, indistinguishable form and short time last from oog

• As carbonic anhydrase catalyzes the reaction of CO

  2020-08-03

  

  As carbonic anhydrase catalyzes the reaction of CO2 and H2O to HCO3− and H+, a cost-effective means of capturing CO2 from industrial emitters, such as coal power plants using carbonic anhydrase have also been studied [31]. CO2 is fixed as HCO3- in aqueous media with carbonic anhydrase, and it can be

• In this work we aimed to deepen our knowledge

  2020-08-03

  

  In this work, we aimed to deepen our knowledge on the functional regulation of the malin–laforin complex. First, we focused our attention on the E2-conjugase that participates in the ubiquitination reaction. We found that the ubiquitin conjugating enzyme E2-N (UBE2N; Ubc13), one of the more than 38

• 5,8,11-Eicosatriynoic Acid australia br Conclusions Mulan is

  2020-08-03

  

  Conclusions Mulan is a mitochondrial E3 ubiquitin ligase with diverse roles in cell growth, cell death, and mitophagy. To better understand the mechanism of Mulan\'s function we used a modified yeast two-hybrid system to isolate proteins that interact with its cytoplasmic RING domain (amino acids

• In some fish a rise in plasma progesterone

  2020-08-03

  

  In some fish a rise in plasma progesterone (P4) levels and changes of mPR abundance in gonads were reported to be associated with oocyte maturation and ovulation (Kagawa et al., 1981, Kazeto et al., 2005b) and sperm mobility is also regulated by non-genomic progesterone actions in fish and mammals

• By using a cohort of

  2020-08-03

  

  By using a cohort of clinical SRCT cases with previously confirmed fusion events, ChildSeq-RNA correctly identified gene fusions in 15 of 16 ES samples, all six aRMS samples, the two DSRCT samples, and one CFS sample. The single failed ES case (which also failed in an RT-PCR experiment that we perfo

• Totally three basic interactional means would happen

  2020-08-03

  

  Totally three basic interactional means would happen when small molecules bind to DNA: intercalation, groove binding as well as electrostatic interactions. The structure of the small molecules is a determinative factor for the binding types. A planar and aromatic structure of a molecule prefers to h

• In apicomplexans the internal NADH dehydrogenase is

  2020-08-03

  

  In apicomplexans, the internal NADH dehydrogenase is suggested to be a critical component of the mitochondrial electron transport chain lacking Complex I (Biagini et al. 2006) and an evolutionary SB-505124 hydrochloride to a microaerophilic lifestyle of parasites that enable uncoupled NADH oxidatio

• In general EphA receptors EphA A

  2020-07-31

  

  In general, EphA receptors (EphA1-A10) are promiscuously activated by ephrinA ligands (ephrinA1-ephrinA6), whereas EphB receptors (EphB1-EphB6) are activated by ephrinB ligands (ephrinB1-ephrinB3). Cross interactions have been observed between EphB2 and ephrinA5 as well as between EphA4 and ephrinB2

14157 records 759/944 page Previous Next First page 上5页 756757758759760 下5页 Last page