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In the present study we combined activity
2020-02-14
In the present study, we combined activity-based protein profiling, biochemical and genetic approaches to identify the PLCPs involved in the sphingolipid pathway leading to plant PCD. By using Arabidopsis MGCD0103 australia and leaves, we demonstrate that this sub-class of plant proteases is activa
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Almost of drugs in the market
2020-02-14
Almost 75% of drugs in the market undergo deactivation though oxidation, reduction or hydrolysis by cytochrome P450 (CYP) enzymes, and then, either directly or by facilitated excretion from the body (Guengerich, 2008). The CYP3A subfamily is of particular interest because of its broad substrate spec
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ICV injection of UCN or UCN performed in the morning
2020-02-14
ICV injection of UCN2 or UCN 3 performed in the morning of the 8th day (12h after the last IP administration) seems to increase further the time spent in the open arms of mice exposed to saline or nicotine treatment. Interestingly, in mice exposed to saline treatment ICV injection of UCN 2 or UCN 3
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The conventional medical therapy for IBD consists in reducin
2020-02-14
The conventional medical therapy for IBD consists in reducing the inflammatory response using various strategies that exert severe side-effects, a strategy that also decreases the risk of colon carcinoma [13], [14]. During the last decade, the activation of the cholinergic system has been proposed f
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One of the therapeutic proteins used
2020-02-14
One of the therapeutic proteins used in cancer therapy is glucarpidase, also known as Carboxypeptidase G2, CPG2, which originates from the bacterium Variovorax paradoxus (old name, Pseudomonas sp. strain RS-16). It has no mammalian equivalent (Thompson et al., 1994; Kamlage, 1994) and is a zinc-depe
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Emi protein consists of an N
2020-02-14
Emi2 protein consists of an N-terminal regulatory region and a C-terminal functional region. The C-terminal region contains a destruction box (D-box), which likely competes with APC/C substrates (including cyclin B) for APC/C binding, and a zinc-binding region (ZBR), which somehow inhibits APC/C ubi
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Taking all the data together we propose
2020-02-14
Taking all the data together, we propose the possible mechanism of glyphosate-induce cell proliferation via estrogen receptor signaling (Fig. 10). Glyphosate may bind to ERα followed by an activation step that starts with the phosphorylation of ERα and activation of other signaling proteins by phos
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RQ-00203078 sale One of the most fundamental distinctions be
2020-02-14
One of the most fundamental distinctions between Ub signals is substrate monoubiquitination versus polyubiquitination. With the exception of the E2, UBE2W, which represents a special case because it RQ-00203078 sale only ubiquitinates the flexible N-termini of substrates [5], [6], [20], most exampl
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br Materials and methods br
2020-02-14
Materials and methods Results Discussion EP is an important tick borne disease caused by T. equi and B. caballi. Current chemotherapeutic drugs for EP are limited, as only diminazene aceturate and imidazole dipropionate are available. Novel and effective chemotherapeutics for treatment of E
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Although enantioselective accumulation of metalaxyl in
2020-02-13
Although enantioselective accumulation of metalaxyl in organisms is an integrated outcome of bio-process including absorption, transportation, and transformation, it is observed in our study that catalysis of CYP450 may lead to the enantioselective accumulation of metalaxyl. However, the mechanisms
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DNA bound Ku proteins recruit DNA PKcs and thereby
2020-02-13
DNA-bound Ku proteins recruit DNA-PKcs; and thereby translocate into the duplex by one helical turn, leaving DNA-PKcs near the DNA terminus to assist in tethering the broken ends together [25]. In addition to keeping the DSBs in close proximity, DNA-PKcs may prevent exonucleolytic degradation of the
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Proteases as multifunctional enzymes play
2020-02-13
Proteases, as multifunctional enzymes, play key roles in controlling a wide variety of cellular and extracellular processes in plants and animals, including protein degradation and processing, germination, complement activation, inflammation, responses to environmental stimuli, senescence and so on.
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Although several examples of selective reduction of diazoest
2020-02-13
Although several examples of selective Iberiotoxin of α-diazoesters to α-hydrazonoesters have been described in the literature, reports on practical and general examples of such a process are scarce. In this context, there was a need to devise a mild and general method for the selective reduction of
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In order to further evaluate cpt
2020-02-13
In order to further evaluate cpt1a function, we determined its tissue distribution in large yellow croaker. The mRNA levels of cpt1a were detected in all the tested tissues, but at varying levels. cpt1a mRNA expression was the highest in liver among different tissues, similar to reports in other fis
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br Methods br Results Our study focused on
2020-02-13
Methods Results Our study focused on consecutive postural adjustments (CPAs) between IS and BS (the shaded areas on Fig. 2); that is to say, the Rx kinetics that occur after the end of an upper limb movement. It was dedicated to examining the main features of CPAs and the influence of movement
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