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The interferences between thapsigargin and
2020-01-03
The interferences between thapsigargin- and forskolin-induced Ca release indicate that these drugs deplete the same intracellular stores in RASMC. In fact, after partial depletion of thapsigargin-sensitive stores, the forskolin-induced increases in [Ca]c were significantly reduced. Similarly, a prev
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In human neuroblastoma SH SY
2020-01-03
In human neuroblastoma SH-SY5Y mefloquine hcl and in lymphoma Jurkat cells, Yamanaka et al. [56] showed that exogenously added 24(S)-hydroxycholesterol could be efficiently esterified by ACAT1. These results suggest that both ACAT1 and ACAT2 can control the oxysterol levels by directly esterifying
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Since ET was discovered first and
2020-01-03
Since ET-1 was discovered first and showed a wide variety of actions not only on the cardiovascular system but also on various other tissues, much information has accumulated on ET-1 compared with the two other peptides. The method for measurement of ET-1 levels in plasma or various tissues by means
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To elucidate whether the impact
2020-01-03
To elucidate whether the impact of hypoxia on EGFR expression is cell context specific or culturing density dependent, we chose the following cancer SJB2-043 driven by EGFR and evaluated the EGFR expression after hypoxia treatment at different culturing density: a highly aggressive and poorly diffe
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We propose two different pathways for the production of this
2020-01-02
We propose two different pathways for the production of this species: either that described by Dooley [24], where the phenol ring is first activated by binding of its oxygen to copper, or one where a copper-peroxo species would directly react with an active site tyrosine residue (Scheme 1B). This se
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br Acknowledgment This work was supported by the Estonian Sc
2020-01-02
Acknowledgment This work was supported by the Estonian Science Foundation (Grant ETF8862). Introduction In higher eukaryotes ionizing-radiation (IR) induced DNA double-strand breaks (DSB) are primarily repaired by the non-homologous end joining (NHEJ) pathway [1]. Ku, a heterodimeric protein
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br Biological roles of DGK br Summary and future perspective
2020-01-02
Biological roles of DGKϵ Summary and future perspectives The most human leukocyte elastase segment of DGKϵ, comprised of residues 20–42, appears to have no role in binding the lipid substrate DAG or in the acyl chain specificity of substrate phosphorylation. Nevertheless, the sequence in this
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PD123319 mg In this review we present
2020-01-02
In this review, we present compelling evidence in support of DHODH as an essential enzyme for the survival of cancer cells. DHODH, and its relationship to de novo pyrimidine metabolism, will be discussed along with factors that influence its regulation and expression. We will show evidence of DHODH\
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br MCADD review br Funding None br Introduction Bacteroides
2020-01-02
MCADD review Funding None. Introduction Bacteroides species are obligate anaerobes, Gram-negative, and non-spore-forming bacteria and 21 species of this genus are found particularly in the oral cavity and gastrointestinal tract in vertebrates [1,2]. B. fragilis is the most common WZB117 au
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The all NTP pyrophosphatase and NUDIX families maintain the
2020-01-02
The all-α NTP pyrophosphatase and NUDIX families maintain the deoxynucleotide triphosphate (dNTP) pool balance, limit the incorporation of harmful nucleotides, and represent a promising therapeutic approach to develop anticancer and immunosuppressive agents., , , , Among these housekeeping enzymes
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br NF B and STAT as Regulators of the CDK
2020-01-02
NF-κB and STAT as Regulators of the CDK System While current data support the concept that CDKs augment the proinflammatory activity of NF-κB, our understanding of the function of this transcription factor system in CDK regulation remains patchy. Seminal studies showed the contribution of NF-κB t
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hyPerFUsion™ high-fidelity PCR Kit T cell infiltration is an
2020-01-02
T cell infiltration is an important predictive biomarker for the PD-1 blockade, and it is closely associated with a good prognosis. In our study, we found that T cells were low and exhausted within the tumor microenvironment and were distributed in the tumor margin. Anti-PD-1 treatment reduced PD-1
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Pasireotide receptor br Results br Discussion Unraveling the
2020-01-02
Results Discussion Unraveling the molecular details of nucleoporin-karyopherin interactions, which have to be strong enough to promote transport but sufficiently weak to avoid stalling of transport complexes within the pore, is key to our understanding of the mechanisms of nucleocytoplasmic tr
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Cryoprotectant equilibration and the response to ice concent
2020-01-02
Cryoprotectant equilibration and the response to ice concentrated media are the two facets of cellular cryobiological protocols most commonly covered by mathematical modeling. In these models, Oxybutynin mg are typically assumed to have uniform, spatially independent extracellular concentrations an
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Since inception of the accelerated program in California has
2020-01-02
Since inception of the accelerated program in 2000, California has varied the requirements for CPA licensure. Prior to 2002, licensure was available with a bachelor’s degree in any subject, 24 semester hours (36 quarter units) of accounting, 24 semester hours (36 quarter units) of general business,
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