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L-NMMA citrate synthesis Kuda et al reported that the activi
2024-06-19
Kuda et al. (1997) reported that the activity of aminopeptidase A (ApA) but not aminopeptidase B (ApB) nor aminopeptidase N (ApN) was decreased in plasma from patients with Alzheimer's disease (AD). More recently Puertas et al. (2013) reported that the activities of plasma ApA, ApB, ApN and IRAP wer
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In human epidermoid carcinoma A cells
2024-06-19
In human epidermoid carcinoma A431 cells, 12-lipoxygenase was significantly increased in glutathione-depleted cells. The relative abundance of phospholipid hydroperoxide versus glutathione peroxidase seems to play an important role in controlling the lipoxygenase reaction [57]. It has been proposed
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Interestingly all of the ROS rearrangements
2024-06-19
Interestingly, all of the ROS1 rearrangements share a constant breakpoint in ROS1 and the fusion product contain the kinase domain resulting in aberrant ROS1 expression with constitutive kinase activity. Intrachromosomal deletions and interchromosomal translocations have demonstrated the existence o
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br Conflict of interest br Introduction The Piezo proteins
2024-06-19
Conflict of interest Introduction The Piezo proteins, Piezo1/FAM38A and Piezo2/FAM38B, are multi-pass transmembrane proteins that have been identified as mechanically-activated (MA) homomultimeric, pore-forming ion channels [1,2]. Piezo1 is broadly expressed with its highest expression in blad
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PKA signalling in the http
2024-06-19
PKA signalling in the nucleus was thought to be due to the translocation of the catalytic subunit upon activation from the FG2216 sale to the nucleus via diffusion [72]. However, a new understanding has emerged, as both the regulatory and catalytic subunits have been identified in the nucleus and f
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br Experiment br Results and discussion br Conclusion br Int
2024-06-19
Experiment Results and discussion Conclusion Introduction Tuberculosis (TB) is a chronic specific bacterial infection caused by bacteria of the Mycobacterium tuberculosis [1]. TB remains one of the deadliest diseases in the world. It is the second leading infectious cause of death after
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Previous reports indicate that the expression
2024-06-19
Previous reports indicate that the expression of AChRs and their clustering on myotubes are critical factors required to induce contacts on muscle fibers in a natural biological system [14], [15], [16], [17], [18], [19]. For instance, in NMJ development in the mouse, AChRs are pre-patterned at sites
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The c C T mutation identified in
2024-06-18
The c.286C>T mutation identified in subject K20-1 was also reported in other ethnic groups, including Brazilian, French-Canadian, Italian, and Arabs from the United Arab Emirates [20], [21], [22], whereas c.318A>G mutation in subjects K10-1 was previously reported in Asian and Caucasians [13], [23],
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Introduction The first use of the term autophagy
2024-06-18
Introduction The first use of the term “autophagy” by a French physiologist, M. Anselmier, in a short article describing the effects of fasting in mice published in 1859, took place almost a century before Christian De Duve described it from a mechanistic point of view in a symposium on lysosomes i
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The overall mechanism of the Cdc complex resembles
2024-06-18
The overall mechanism of the Cdc48 complex resembles that of the 19S regulatory subunit of the proteasome, which also uses receptor proteins to bind polyubiquitin chains attached to a substrate and employs a translocation mechanism (for review, see Kish-Trier and Hill, 2013). As with Cdc48, full sub
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Significant reductions in GYN cancer patient mortality and m
2024-06-18
Significant reductions in GYN cancer patient mortality and morbidity rates require treatments that proactively prevent and reverse resistance to chemotherapy and radiation. Combining chemotherapy and radiation with inhibitors of key DDR proteins targets is likely to enhance the ability of genotoxic
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Apoptozole br In vivo visualization of aromatase with positr
2024-06-18
In vivo visualization of aromatase with positron emission tomography (PET) Positron emission tomography (PET) utilizes the high Apoptozole photons formed during the annihilation of positrons to detect the changes in the amount and localization of injected radiopharmaceuticals in the living body
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br Combination Effective RAS inhibition which
2024-06-18
Combination Effective RAS inhibition, which is important for GST Peptide control as well for the management of associated illnesses, can be produced through proper selection and dose maintenance and also by the combination with other antihypertensive agents along with continuous monitoring for si
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The apocrine sweat glands of the human axilla produce odor
2024-06-18
The apocrine sweat glands of the human axilla produce odor substances with pheromone functions whose nature corresponds to volatile steroids (Cowley and Brooksbank, 1991, Grosser et al., 2000, Sobel et al., 1999, Weller, 1998). These functions only begin with puberty, indicating that sex hormones st
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When arachidonic acid is used as a
2024-06-18
When arachidonic 3576 sale is used as a substrate, the platelet-type 12S-lipoxygenase produces predominantly the 12S-hydroperoxy derivative. In contrast, the leukocyte-type 12S-lipoxygenases generate substantial amounts of the 15-lipoxygenase product in addition to the 12S-hydroperoxy derivative. Th
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