2025-09-24

Explore how 2'3'-cGAMP (sodium salt) advances our understanding of cancer immunotherapy through its unique activation of endothelial STING-JAK1 signaling. This article offers a scientific deep-dive into cyclic GMP-AMP's role in tumor vasculature normalization and next-generation immunotherapy research.

2'3'-cGAMP (sodium salt): Expanding Horizons in STING-Med...

2025-09-23

Explore the multifaceted roles of 2'3'-cGAMP (sodium salt) in activating the STING pathway, with a focus on recent discoveries in endothelial cell signaling and implications for cancer immunotherapy. This article offers advanced insights into cyclic GMP-AMP–driven type I interferon induction and the evolving landscape of immunotherapy research.

2'3'-cGAMP (sodium salt): Dissecting Cell-Specific STING ...

2025-09-22

This article explores 2'3'-cGAMP (sodium salt) as a precise molecular tool for dissecting cell-type–specific signaling in the cGAS-STING pathway, with a focus on its implications for cancer immunotherapy and antiviral innate immunity. We highlight new research revealing endothelial-specific STING-JAK1 interactions and discuss how these insights can refine experimental approaches.

2'3'-cGAMP (sodium salt): Advancing STING Agonist Applica...

2025-09-19

Explore the mechanistic and translational insights of 2'3'-cGAMP (sodium salt), a potent STING agonist, in modulating tumor vasculature and type I interferon induction. This article provides a rigorous analysis of its utility in cancer immunotherapy research and antiviral innate immunity, integrating recent advances in the cGAS-STING signaling pathway.

2'3'-cGAMP (sodium salt): Unraveling Endothelial-STING Dy...

2025-09-18

Explore how 2'3'-cGAMP (sodium salt), a potent STING agonist, advances our understanding of endothelial STING-mediated innate immune responses and tumor vasculature normalization. This article highlights recent mechanistic insights and practical research applications for cancer immunotherapy.

According to their structures and substrate

2025-03-03

According to their structures and substrate specificity, MMPs are divided into five major groups: collagenases (e.g., MMP1), gelatinases (e.g., MMP2, MMP9), stromelysins (e.g., MMP3, MMP10), matrilysins (e.g., MMP7), and membrane-type MMPs [7]. Among them, MMP1 is a major collagenase that degrades t

To confirm a role of OCT

2025-03-03

To confirm a role of OCT3 in corticosterone-induced potentiation of cocaine-primed reinstatement, we examined the interaction of corticosterone and cocaine in the reinstatement of cocaine conditioned place preference (CPP) in wild type mice, and transgenic OCT3-deficient mice. These mice express a t

ezh2 inhibitor br Introduction Nausea and vomiting are among

2025-03-03

Introduction Nausea and vomiting are among the most distressing side effects associated with chemotherapy in cancer patients (Billio et al., 2010). Severe emesis can negatively affect a patient's nutritional state, ability to work and motivation, which can, in turn, interfere with the clinical co

Curcumin is the principal natural polyphenol curcuminoid of

2025-03-03

Curcumin is the principal natural polyphenol curcuminoid of turmeric (Curcuma longa) rhizome, a member of the ginger family (Zingiberaceae) [13]. Curcumin has a wide spectrum of therapeutic properties, and it has been shown to possess antioxidant, anti-inflammatory, anticancer, antiangiogenesis, che

The purpose of the present study is to characterize

2025-03-03

The purpose of the present study is (1) to characterize AChE from the monogonont B. koreanus and to analyze the modulation of the AChE activity and its transcription level after exposure to six pharmaceuticals, (2) to evaluate the usefulness of AChE as a molecular biomarker upon pharmaceutical expos

The anorexic effect observed when AR is infused into

2025-03-03

The anorexic effect observed when AR231630 is infused into the VTA could be the result of the DA release inhibition, as previously described [11]. However, there is also a hedonic aspect in feeding that possibly involves dopaminergic mechanisms of reward. Helm et al. showed a functional link between

Human leukemic blasts from both AML and ALL patients

2025-03-01

Human leukemic blasts from both AML and ALL patients demonstrated 5-, 12-, and 15-LOX expression [54]; however, using quantitative PCR, 5-LOX was much more prevalent than 15-LOX. When 15-HETE, 12-HETE, and LTB4 were tested for a direct effect on leukemic blasts, none induced apoptosis [54]. In contr

In response to DSB the

2025-03-01

In response to DSB, the lesion recognition factor Mre11-Rad50-Nbs1 (MRN) complex helps the recruitment of ATM to the damage site and its activation by phosphorylation [29]. However, whether UV-damage recognition factors directly influence ATR and ATM recruitment and their phosphorylation is not clea

ARG I is one of the most important mammalian enzymes

2025-03-01

ARG I is one of the most important mammalian enzymes responsible for nitrogen metabolism since it comprises the main route for the elimination of excess nitrogen resulting from amino C-type natriuretic peptide (1-22) (human, rat, swine) and nucleotide metabolism [18]. ARG I deficiency leads to hype

Although the gene that encodes

2025-03-01

Although the gene that encodes DHFR has been strongly conserved during evolution, subtle differences in the active sites of bacterial, human and parasite Tenovin-3 have been exploited to develop DHFR inhibitors specific to particular pathogens 1, 3. For example, pyrimethamine and cycloguanil bind s