Archives
- 2018-07
- 2019-07
- 2019-08
- 2019-09
- 2019-10
- 2019-11
- 2019-12
- 2020-01
- 2020-02
- 2020-03
- 2020-04
- 2020-05
- 2020-06
- 2020-07
- 2020-08
- 2020-09
- 2020-10
- 2020-11
- 2020-12
- 2021-01
- 2021-02
- 2021-03
- 2021-04
- 2021-05
- 2021-06
- 2021-07
- 2021-08
- 2021-09
- 2021-10
- 2021-11
- 2021-12
- 2022-01
- 2022-02
- 2022-03
- 2022-04
- 2022-05
- 2022-06
- 2022-07
- 2022-08
- 2022-09
- 2022-10
- 2022-11
- 2022-12
- 2023-01
- 2023-02
- 2023-03
- 2023-04
- 2023-05
- 2023-06
- 2023-08
- 2023-09
- 2023-10
- 2023-11
- 2023-12
- 2024-01
- 2024-02
- 2024-03
- 2024-04
- 2024-05
- 2024-06
- 2024-07
- 2024-08
- 2024-09
- 2024-10
- 2024-11
- 2024-12
- 2025-01
- 2025-02
- 2025-03
- 2025-09
-
Leucovorin Calcium: Optimizing Methotrexate Rescue in Tum...
2025-09-30
Leucovorin Calcium, a potent folate analog, is redefining methotrexate rescue and antifolate drug resistance research in complex tumor assembloid systems. This guide details applied workflows, troubleshooting strategies, and advanced use-cases to maximize experimental success.
-
Leucovorin Calcium: Mechanisms and Advanced Applications ...
2025-09-29
Explore the multifaceted role of Leucovorin Calcium, a crucial folate analog for methotrexate rescue and antifolate drug resistance research. This article offers an in-depth scientific analysis of its mechanisms, unique applications in personalized cancer models, and future directions in chemotherapy adjunct strategies.
-
2'3'-cGAMP (sodium salt): Next-Generation Insights in STI...
2025-09-28
Explore the cutting-edge role of 2'3'-cGAMP (sodium salt) as a potent STING agonist in cancer immunotherapy and antiviral innate immunity. This article uniquely focuses on strategic design, optimization, and translational challenges, offering a scientific perspective distinct from existing reviews.
-
2'3'-cGAMP (Sodium Salt): Unraveling Noncanonical STING-J...
2025-09-27
Explore how 2'3'-cGAMP (sodium salt) advances cancer immunotherapy by uniquely dissecting the interplay between STING and JAK1 signaling. This article offers a deep dive into type I interferon induction and novel mechanisms distinct from conventional cGAS-STING pathway studies.
-
2'3'-cGAMP (sodium salt): Advanced Insights for Engineeri...
2025-09-26
Explore how 2'3'-cGAMP (sodium salt) redefines research on the cGAS-STING signaling pathway and type I interferon induction. This article offers a unique systems immunology perspective on leveraging this STING agonist for next-generation cancer immunotherapy and antiviral innate immunity.
-
2'3'-cGAMP (sodium salt): Unlocking Endothelial STING Sig...
2025-09-25
Explore the pivotal role of 2'3'-cGAMP (sodium salt) in modulating endothelial STING signaling for advanced immunotherapy research. This in-depth analysis reveals emerging mechanisms and translational opportunities beyond standard innate immune activation.
-
2025-09-24
Explore how 2'3'-cGAMP (sodium salt) advances our understanding of cancer immunotherapy through its unique activation of endothelial STING-JAK1 signaling. This article offers a scientific deep-dive into cyclic GMP-AMP's role in tumor vasculature normalization and next-generation immunotherapy research.
-
2'3'-cGAMP (sodium salt): Expanding Horizons in STING-Med...
2025-09-23
Explore the multifaceted roles of 2'3'-cGAMP (sodium salt) in activating the STING pathway, with a focus on recent discoveries in endothelial cell signaling and implications for cancer immunotherapy. This article offers advanced insights into cyclic GMP-AMP–driven type I interferon induction and the evolving landscape of immunotherapy research.
-
2'3'-cGAMP (sodium salt): Dissecting Cell-Specific STING ...
2025-09-22
This article explores 2'3'-cGAMP (sodium salt) as a precise molecular tool for dissecting cell-type–specific signaling in the cGAS-STING pathway, with a focus on its implications for cancer immunotherapy and antiviral innate immunity. We highlight new research revealing endothelial-specific STING-JAK1 interactions and discuss how these insights can refine experimental approaches.
-
2'3'-cGAMP (sodium salt): Advancing STING Agonist Applica...
2025-09-19
Explore the mechanistic and translational insights of 2'3'-cGAMP (sodium salt), a potent STING agonist, in modulating tumor vasculature and type I interferon induction. This article provides a rigorous analysis of its utility in cancer immunotherapy research and antiviral innate immunity, integrating recent advances in the cGAS-STING signaling pathway.
-
2'3'-cGAMP (sodium salt): Unraveling Endothelial-STING Dy...
2025-09-18
Explore how 2'3'-cGAMP (sodium salt), a potent STING agonist, advances our understanding of endothelial STING-mediated innate immune responses and tumor vasculature normalization. This article highlights recent mechanistic insights and practical research applications for cancer immunotherapy.
-
According to their structures and substrate
2025-03-03
According to their structures and substrate specificity, MMPs are divided into five major groups: collagenases (e.g., MMP1), gelatinases (e.g., MMP2, MMP9), stromelysins (e.g., MMP3, MMP10), matrilysins (e.g., MMP7), and membrane-type MMPs [7]. Among them, MMP1 is a major collagenase that degrades t
-
To confirm a role of OCT
2025-03-03
To confirm a role of OCT3 in corticosterone-induced potentiation of cocaine-primed reinstatement, we examined the interaction of corticosterone and cocaine in the reinstatement of cocaine conditioned place preference (CPP) in wild type mice, and transgenic OCT3-deficient mice. These mice express a t
-
ezh2 inhibitor br Introduction Nausea and vomiting are among
2025-03-03
Introduction Nausea and vomiting are among the most distressing side effects associated with chemotherapy in cancer patients (Billio et al., 2010). Severe emesis can negatively affect a patient's nutritional state, ability to work and motivation, which can, in turn, interfere with the clinical co
-
Curcumin is the principal natural polyphenol curcuminoid of
2025-03-03
Curcumin is the principal natural polyphenol curcuminoid of turmeric (Curcuma longa) rhizome, a member of the ginger family (Zingiberaceae) [13]. Curcumin has a wide spectrum of therapeutic properties, and it has been shown to possess antioxidant, anti-inflammatory, anticancer, antiangiogenesis, che